Head of Translational Medicine Job at Sarepta Therapeutics, Inc., Cambridge, MA

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  • Sarepta Therapeutics, Inc.
  • Cambridge, MA

Job Description

Why Sarepta? Why Now?
The promise of genetic medicine has arrived, and Sarepta is at the forefront. We hold leadership positions in Duchenne muscular dystrophy (DMD) and limb-girdle muscular dystrophies (LGMDs), and we currently have more than 40 programs in various stages of development in gene therapy, RNA and gene editing. In 2023, we launched our fourth therapy and the first ever gene therapy to treat Duchenne.

We're looking for people who see unlimited potential in themselves and who are motivated by an unwavering commitment to patients.

What Sarepta Offers

At Sarepta, we care deeply about all the people in our community and believe in the importance of supporting them in all aspects of their lives. We aspire to maintain a culture that acknowledges people bring their whole selves to work, and we will strive to help everyone in our community integrate their work and personal lives while maintaining productivity. We are committed to offering a range of benefits and work-life resources designed to support people in the following areas:
  • Physical and Emotional Wellness
  • Financial Wellness
  • Support for Caregivers
For a full list of our comprehensive benefits, see our website:

The Importance of the Role
The Head of Translational Medicine would oversee the translational medicine initiatives, particularly focusing on the integration of imaging biomarkers, particularly MRI outcomes, into our development programs. This individual would be responsible for driving the translational strategy from preclinical stages through clinical trials, ensuring that innovative imaging techniques are effectively applied to enhance our understanding of therapeutics efficacy, especially in muscle and cardiac tissue.

The Opportunity to Make a Difference
  • Lead the translational strategy for the integration of imaging biomarkers into both preclinical and clinical development programs.
  • Collaborate closely with cross-functional teams to align translational medicine goals with overall development objectives.
  • Drive reverse translation by leveraging clinical trial data to inform preclinical research, particularly focusing on mechanism studies and hypothesis testing.
  • Provide scientific leadership in the application of MRI technology for muscle and cardiac imaging within the context of biomarker discovery and development, including external collaborations that use imaging biomarkers to define disease natural history
  • Develop and implement strategies to incorporate advanced imaging biomarkers into clinical protocols, ensuring alignment with regulatory and clinical endpoints.
  • Oversee the design and execution of preclinical and clinical studies involving imaging biomarkers, ensuring high standards of scientific rigor and data quality.
  • Act as a scientific and strategic liaison with external partners, including key opinion leaders and regulatory bodies, to drive the successful implementation of imaging technologies in drug development.
  • Identify and champion novel imaging techniques and digital biomarkers that can be integrated into the drug development process to enhance patient selection, treatment monitoring, and therapeutic outcomes.
  • Ensure continuous improvement of translational methodologies by staying abreast of emerging technologies and scientific advancements.

More about You
  • MD or PhD in a relevant field such as Radiology, Medical Imaging, or Biomedical Sciences.
  • A minimum of 11+ years of experience in the biopharma or biotechnology industry or relevant academic experience, with a proven track record in translational medicine or imaging biomarker development.
  • Extensive experience in MRI technology with a strong focus on muscle and cardiac imaging.
  • Demonstrated ability to lead cross-functional teams in a matrix environment and effectively collaborate with external partners.
  • Strong understanding of the regulatory landscape and experience in preparing and submitting regulatory documents.
  • Excellent communication and leadership skills, with the ability to influence and drive projects forward in a fast-paced environment.

What Now?

We're always looking for solution-oriented, critical thinkers.

So, if you're comfortable with ambiguity and candor, relish challenging yourself, and place kindness and integrity at the forefront of how you approach your peers and work, then we encourage you to apply.


#LI-Hybrid

#LI-TD1

This position is hybrid, you will be expected to work on site at one of Sarepta's facilities in the United States and/or attend Company-sponsored in-person events from time to time.

The targeted salary range for this position is $248,000 - $310,000 per year. Sarepta is making a good faith effort to be transparent and accurate around our hiring ranges. The salary offer is commensurate with Sarepta's compensation philosophy and considers factors including, but not limited to, education, training, experience, external market conditions, criticality of role, and internal equity.

Candidates must be authorized to work in the U.S.

Sarepta Therapeutics offers a competitive compensation and benefit package.

Sarepta Therapeutics is an Equal Opportunity/Affirmative Action employer and participates in e-Verify.

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